Self-Management for Health in Chronic Conditions (R01 Clinical Trial Optional) | PA 18 376

Opportunity Information: Apply for PA 18 376

The National Institutes of Health (NIH) funding opportunity titled "Self-Management for Health in Chronic Conditions (R01 Clinical Trial Optional)" (Funding Opportunity Number PA 18 376) supports research projects that strengthen the scientific foundation for self-management in people living with chronic illnesses or long-term health conditions. The central idea is to treat self-management as a mainstream, rigorous area of health science rather than as a side topic, with the goal of reducing the overall burden that chronic diseases place on individuals, families, and health systems. Projects supported under this announcement are expected to advance knowledge about how people manage chronic conditions in real life and how those self-management processes can be improved, scaled, and sustained across different settings and populations.

This opportunity uses the NIH R01 grant mechanism, which is designed for substantial, hypothesis-driven research programs that can produce meaningful, generalizable findings. The "clinical trial optional" designation means applicants may propose studies that include clinical trials, but they are not required to do so; non-trial research that still meaningfully advances self-management science is also within scope. The funding instrument type is a grant, and the activity categories are listed as education and health, reflecting the applied, behaviorally grounded nature of many self-management interventions and implementation strategies.

A wide range of applicants are eligible, which opens the door to interdisciplinary and community-connected research teams. Eligible applicants include state, county, and local governments; special district governments; independent school districts; and public housing authorities/Indian housing authorities. Both public and private institutions of higher education can apply, including public and state-controlled universities. Tribal governments (federally recognized) and Native American tribal organizations (including those other than federally recognized governments) are eligible, as are nonprofit organizations with or without 501(c)(3) status, and for-profit organizations (other than small businesses) as well as small businesses. The FOA also explicitly highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs). It further includes faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations), signaling an interest in broad participation and approaches that can address diverse communities and contexts.

In practical terms, the FOA is aimed at research that can clarify what makes self-management effective, for whom, and under what conditions, while also helping to develop and test strategies that empower individuals to manage symptoms, treatment regimens, lifestyle changes, and the day-to-day challenges that come with chronic conditions. Because the announcement emphasizes building "the science" of self-management, strong proposals would typically go beyond simply delivering a program and measuring outcomes; they would also try to unpack mechanisms, refine intervention components, improve measurement, address barriers to adoption and maintenance, and generate insights that can transfer across diseases, settings, or populations. The overarching outcome NIH is pushing toward is a stronger evidence base that can be used to reduce morbidity, improve quality of life, and lessen health system strain by supporting people in managing chronic illness more effectively.

Key administrative details from the listing include the NIH as the sponsoring agency, the original posting timeframe (created December 18, 2017), and an original closing date of January 7, 2021, as provided in the source data. The CFDA numbers associated with this opportunity are 93.361 and 93.866, which are identifiers used for federal assistance programs. The award ceiling and expected number of awards are not specified in the provided data, so applicants would typically look to the full FOA text or NIH institute-specific budget guidance for practical limits and expectations.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Self-Management for Health in Chronic Conditions (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361, 93.866.
• This funding opportunity was created on 2017-12-18.
• Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 18 376

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