Opportunity Information: Apply for PAR 25 247
Institutional Training Programs to Advance Translational Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (PAR-25-247) is a National Institutes of Health (NIH) discretionary grant opportunity that uses the T32 institutional training mechanism and is specifically marked "Clinical Trial Not Allowed." The core aim is workforce development: building a strong, diverse, and genuinely interdisciplinary pipeline of scientists who can move AD/ADRD research forward across the translational spectrum, from early target discovery and disease mechanism work through stages that inform clinical development. Rather than funding a single research project, this program is designed to fund structured institutional training environments that consistently produce researchers prepared to tackle the complexity of Alzheimer's and related dementias.
The NOFO focuses on supporting training programs for both predoctoral and postdoctoral trainees. NIH is looking for institutions to create or strengthen programs that bring together trainees from different educational and technical backgrounds, including basic biology, translational and clinical research, and data science. A central theme is cross-training: programs are expected to equip trainees with a blend of competencies that reflect how modern AD/ADRD research is actually done, where progress often depends on combining computational methods, rigorous disease biology, behavioral research, and drug discovery approaches. The training emphasis includes both traditional and emerging drug discovery disciplines, signaling interest in preparing scientists who understand the full set of tools used today, such as target identification and validation, biomarker-related thinking, preclinical model strategy, and data-driven methods that can help bridge lab findings to clinically relevant insights.
In practical terms, the opportunity invites eligible institutions to propose interdisciplinary training programs that provide formalized mentoring, coursework or structured learning, and career development experiences that collectively prepare trainees to conduct high-quality basic, translational, and clinically relevant research on AD/ADRD. Even though the notice references the continuum up to clinical development, the "Clinical Trial Not Allowed" designation means the training grant itself should not propose or support clinical trial activities as part of the funded work. The intent is preparation and research training, not running trials under this award.
Eligibility is broad across U.S.-based organizations and includes many types of government entities and educational institutions. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits (with or without 501(c)(3) status) other than institutions of higher education; for-profit organizations other than small businesses; small businesses; and other eligible entities. The NOFO also explicitly highlights additional eligible applicants and encouraged institution types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized entities, and U.S. territories or possessions. At the same time, the notice makes clear that non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible.
The opportunity is categorized under Health (CFDA 93.866) and is offered as a grant. The original closing date listed is 2026-09-25. An award ceiling is not specified in the provided source information, and the expected number of awards is not listed. Overall, this NOFO is best understood as NIH investing in the training infrastructure needed to produce the next generation of AD/ADRD translational researchers who can operate across disciplines, handle modern data and biological complexity, and contribute to a stronger, more diverse scientific workforce focused on dementia-related therapeutic and translational challenges.Apply for PAR 25 247
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Institutional Training Programs to Advance Translational Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (T32 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2024-12-13.
- Applicants must submit their applications by 2026-09-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the funding opportunity?
This opportunity is the NIH notice of funding opportunity (NOFO) titled Institutional Training Programs to Advance Translational Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (PAR-25-247). It is a discretionary grant program that uses the T32 institutional training mechanism.
What is the main purpose of this NOFO?
The core aim is workforce development. The program is designed to build a strong, diverse, and genuinely interdisciplinary pipeline of scientists who can advance AD/ADRD research across the translational spectrum, from early discovery and disease mechanisms through stages that inform clinical development.
Does this program fund a single research project?
No. This program is not designed to fund one specific research project. Instead, it supports structured institutional training environments that consistently produce trainees prepared to work on the complexity of Alzheimer's disease and related dementias.
What training mechanism does the program use?
The NOFO uses the NIH T32 institutional training mechanism, which supports institution-led, organized training programs.
Are clinical trials allowed under this opportunity?
No. The opportunity is explicitly designated "Clinical Trial Not Allowed." The training grant application should not propose or support clinical trial activities as part of the work funded by this award.
If clinical trials are not allowed, why does the NOFO mention clinical development?
The NOFO emphasizes training across the translational continuum up to stages that inform clinical development. The intent is to prepare trainees with relevant translational skills and perspectives, but not to conduct clinical trials under the award.
Who is this program intended to train?
The NOFO focuses on training programs that support both predoctoral and postdoctoral trainees.
What kinds of disciplines or backgrounds are expected in the training program?
The program emphasizes interdisciplinary participation, including trainees with backgrounds in basic biology, translational and clinical research, and data science. A central theme is cross-training across these areas.
What does "cross-training" mean in the context of this NOFO?
Cross-training refers to building programs that equip trainees with a blend of competencies aligned with modern AD/ADRD research, where progress often requires combining computational methods, rigorous disease biology, behavioral research, and drug discovery approaches.
What research areas does the training program aim to cover?
The NOFO highlights preparation for high-quality basic, translational, and clinically relevant AD/ADRD research, with an emphasis on skills that help bridge laboratory findings to clinically meaningful insights.
Is drug discovery training part of the focus?
Yes. The NOFO references both traditional and emerging drug discovery disciplines and signals interest in preparing scientists who understand tools and approaches such as target identification and validation, biomarker-related thinking, preclinical model strategy, and data-driven methods.
What does NIH expect institutions to build or provide through this award?
NIH is looking for institutions to create or strengthen interdisciplinary training programs that include formalized mentoring, coursework or structured learning, and career development experiences that prepare trainees for translational AD/ADRD research.
Who can apply for this funding?
Eligibility is broad across U.S.-based organizations. Eligible applicants include various government entities, educational institutions, tribal entities and organizations, nonprofits, for-profit organizations (other than small businesses), small businesses, and other eligible entities as described in the NOFO information provided.
Are institutions of higher education eligible to apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are government entities eligible to apply?
Yes. Eligible applicants include state, county, city or township governments, and special district governments, among others listed.
Are tribal entities eligible to apply?
Yes. Eligible applicants include federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments. The NOFO information also highlights Indian/Native American tribal governments other than federally recognized entities among additional eligible or encouraged institution types.
Are nonprofits eligible to apply?
Yes. Eligible applicants include nonprofits (with or without 501(c)(3) status) other than institutions of higher education.
Are for-profit organizations eligible to apply?
Yes. The eligibility list includes for-profit organizations other than small businesses as well as small businesses.
Are U.S. territories or possessions included in the eligible applicant types?
Yes. The NOFO information explicitly highlights U.S. territories or possessions among additional eligible applicants and encouraged institution types.
Are foreign (non-U.S.) organizations eligible to apply?
No. The NOFO information states that non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can a U.S. organization apply if the proposed work includes a non-U.S. component?
No. The NOFO information indicates that non-domestic components of U.S. organizations are not eligible.
Does the NOFO encourage applications from specific institution types?
Yes. The NOFO information explicitly highlights and encourages a range of institution types, including HBCUs, HSIs, TCCUs, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and certain tribal entities.
What is the program area or category for this opportunity?
The opportunity is categorized under Health with CFDA 93.866.
What type of funding instrument is this?
The opportunity is offered as a grant.
What is the application closing date?
The original closing date listed in the provided information is 2026-09-25.
Is there an award ceiling listed?
No. Based on the provided information, an award ceiling is not specified.
Is the expected number of awards listed?
No. Based on the provided information, the expected number of awards is not listed.
What is NIH ultimately investing in through this NOFO?
NIH is investing in the training infrastructure needed to produce the next generation of translational AD/ADRD researchers who can work across disciplines, handle modern data and biological complexity, and strengthen and diversify the scientific workforce focused on dementia-related translational and therapeutic challenges.
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