Opportunity Information: Apply for RFA RM 22 009
The Somatic Mosaicism across Human Tissues (SMaHT) Program: Organizational Center (U24 Clinical Trial Not Allowed) funding opportunity (RFA-RM-22-009) is a National Institutes of Health (NIH) cooperative agreement aimed at creating the central coordinating hub for the SMaHT Network. The broader SMaHT Network is intended to accelerate discovery of how somatic genomic variation (genetic changes that arise after conception and are present in some cells or tissues but not others) contributes to fundamental biology and to disease mechanisms across human tissues. Rather than funding a single research project, this particular award supports the infrastructure and leadership needed to keep a multi-site, multi-team consortium functioning smoothly and productively.
At its core, the Organizational Center is designed to be the operational backbone of the SMaHT Network. The center is expected to coordinate network-wide meetings and working sessions, manage day-to-day communication across participating groups, and support outreach activities that connect the network to related programs and to the wider scientific community. In practical terms, this means serving as the organizing point for cross-team collaboration, helping align goals and timelines, facilitating information flow, and creating consistent processes so that the network can operate as a unified effort rather than a set of disconnected projects. The FOA emphasizes that the center should act as the main conduit for collaboration, which signals an expectation that it will actively build bridges among SMaHT-funded components and external stakeholders, not simply schedule meetings.
The award mechanism is a U24 cooperative agreement, which typically indicates substantial NIH program involvement in shaping priorities, oversight, and coordination as the program evolves. The FOA explicitly states that clinical trials are not allowed under this opportunity, reinforcing that the purpose of the Organizational Center is coordination, support, and network enablement rather than testing interventions in human participants. The activity category is Health, and the opportunity is listed under CFDA 93.310. While an award ceiling and expected number of awards are not specified in the provided source data, the structure and language make clear that NIH is seeking a single organizing entity capable of supporting a complex consortium with significant logistical and collaborative demands.
Eligibility is broad and includes many types of domestic applicants across government, academia, nonprofit, and industry. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses. The FOA also calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions. At the same time, it draws a firm boundary around foreign involvement: non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. This means the Organizational Center and its supported activities must remain fully domestic in terms of applicant organization and component performance.
From a programmatic standpoint, the value of this Organizational Center is that it enables the science by strengthening the network. Large-scale efforts focused on somatic mosaicism across tissues require coordinated standards, efficient collaboration, regular alignment on methods and deliverables, and active community engagement so that findings, tools, and resources can be shared and used broadly. The FOA frames the center as the mechanism that makes that coordination possible, ensuring the network can consistently communicate internally, represent itself externally, and interface effectively with related initiatives. The application deadline listed in the source data was July 8, 2022, and the FOA was created on February 23, 2022, placing it within a defined time window for establishing the coordinating infrastructure at the outset of the SMaHT Network.Apply for RFA RM 22 009
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Somatic Mosaicism across Human Tissues (SMaHT) Program: Organizational Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on 2022-02-23.
- Applicants must submit their applications by 2022-07-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the SMaHT Program Organizational Center funding opportunity?
The Somatic Mosaicism across Human Tissues (SMaHT) Program: Organizational Center funding opportunity (RFA-RM-22-009) is an NIH cooperative agreement designed to establish the central coordinating hub for the SMaHT Network. It supports the infrastructure, leadership, and coordination functions needed to keep a multi-site, multi-team consortium running smoothly and productively.
What is the main goal of the broader SMaHT Network?
The SMaHT Network is intended to accelerate discovery of how somatic genomic variation (genetic changes arising after conception that are present in some cells or tissues but not others) contributes to fundamental biology and disease mechanisms across human tissues.
Is this award meant to fund a single research project?
No. This award is focused on supporting coordination and network enablement rather than funding a single, standalone research project. The Organizational Center functions as the operational backbone of the SMaHT Network.
What does the Organizational Center do for the SMaHT Network?
The Organizational Center is expected to serve as the central coordinating hub, including organizing network-wide meetings and working sessions, managing day-to-day communication across participating groups, supporting outreach activities, and helping align goals, timelines, and consistent processes so the network operates as a unified effort.
What kinds of coordination activities are expected?
Based on the description provided, expected activities include coordinating meetings and working sessions, facilitating cross-team collaboration, managing communication across participating groups, supporting outreach to related programs and the broader scientific community, and acting as the main conduit for collaboration among SMaHT-funded components and external stakeholders.
Does the FOA expect the center to be active in building collaborations?
Yes. The FOA emphasizes that the center should be the main conduit for collaboration, indicating an expectation that it will actively build bridges among SMaHT-funded components and external stakeholders, not merely handle scheduling or administrative logistics.
What is the funding mechanism for this opportunity?
The mechanism is a U24 cooperative agreement.
What does a U24 cooperative agreement imply for NIH involvement?
A U24 cooperative agreement typically indicates substantial NIH program involvement in shaping priorities, oversight, and coordination as the program evolves. In this context, the NIH is expected to have an active role consistent with cooperative agreement structures.
Are clinical trials allowed under this opportunity?
No. The FOA explicitly states that clinical trials are not allowed (U24 Clinical Trial Not Allowed). This reinforces that the Organizational Center is intended for coordination, support, and network enablement rather than testing interventions in human participants.
What is the activity category and CFDA listing for this opportunity?
The activity category is Health, and the opportunity is listed under CFDA 93.310.
How many awards will be made, and what is the award ceiling?
The provided source information does not specify an award ceiling or an expected number of awards. However, the description indicates NIH is seeking a single organizing entity capable of supporting a complex consortium.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic (U.S.-based) applicants across government, academia, nonprofit, and industry. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses.
Are any specific institution types highlighted as eligible?
Yes. Additional categories called out as eligible include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.
Are foreign organizations eligible to apply?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can a U.S. organization apply if it proposes work through a non-U.S. component?
No. Non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed. The Organizational Center and its supported activities must remain fully domestic in terms of applicant organization and component performance.
Why is the Organizational Center important for somatic mosaicism research?
Large-scale efforts focused on somatic mosaicism across tissues require coordinated standards, efficient collaboration, regular alignment on methods and deliverables, and active community engagement so findings, tools, and resources can be shared and used broadly. The Organizational Center is framed as the mechanism that makes that network-wide coordination possible.
What kinds of external engagement or outreach are expected?
The center is expected to support outreach activities that connect the network to related programs and to the wider scientific community, helping the network represent itself externally and interface effectively with related initiatives.
What is the FOA number and title for this opportunity?
The FOA is RFA-RM-22-009, titled "The Somatic Mosaicism across Human Tissues (SMaHT) Program: Organizational Center (U24 Clinical Trial Not Allowed)."
When was this FOA created and what was the application deadline?
The FOA was created on February 23, 2022, and the application deadline listed in the provided information was July 8, 2022.
Is this opportunity intended to help launch the SMaHT Network?
Based on the provided dates and description, the Organizational Center is positioned to establish coordinating infrastructure at the outset of the SMaHT Network within the FOA's defined time window.
What is the central theme of work supported by this award?
The central theme is network operations: coordination, communication, collaboration facilitation, outreach, and consistent processes that enable multiple teams and sites to function as a unified consortium.
Browse more opportunities from the same category: Health
Next opportunity: Enhancing Social Connectedness and Ameliorating Loneliness to Prevent and Treat SUD and Support Recovery (R21 - Clinical Trial Not Allowed)
Previous opportunity: U.S. Consulate General São Paulo Public Affairs Section Annual Program Statement FY 2021
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA RM 22 009
Applicants also applied for:
Applicants who have applied for this opportunity (RFA RM 22 009) also looked into and applied for these:
| Funding Opportunity |
|---|
| Somatic Mosaicism across Human Tissues (SMaHT) Program: Data Analysis Center (UM1 Clinical Trial Not Allowed) Apply for RFA RM 22 010 Funding Number: RFA RM 22 010 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Immune Drivers of Autoimmune Disease (IDAD) (U01 Clinical Trial Not Allowed) Apply for RFA AI 22 012 Funding Number: RFA AI 22 012 Agency: National Institutes of Health Category: Health Funding Amount: $750,000 |
| Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed) Apply for RFA RM 22 013 Funding Number: RFA RM 22 013 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (U24 Clinical Trial Not Allowed) Apply for RFA RM 22 012 Funding Number: RFA RM 22 012 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Studies of Cytosolic DNAs in the Interactions of Aging Hallmarks (R01 Clinical Trial Not Allowed) Apply for RFA AG 23 015 Funding Number: RFA AG 23 015 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Inter-Organelle Communication as a Platform to Interrogate the Interactions of Hallmarks of Aging (R01 Clinical Trial Not Allowed) Apply for RFA AG 23 012 Funding Number: RFA AG 23 012 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Mapping Interconnectivity Among Hallmarks of Aging under Lifespan Modifications (R01 Clinical Trial Not Allowed) Apply for RFA AG 23 013 Funding Number: RFA AG 23 013 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Noncoding RNAs in Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed) Apply for RFA AG 23 010 Funding Number: RFA AG 23 010 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Noncoding RNAs in Alzheimers Disease and Related Dementias (R21 Clinical Trial Not Allowed) Apply for RFA AG 23 011 Funding Number: RFA AG 23 011 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NEI Clinical Research Study Planning Grant Program (R34 Clinical Trial Not Allowed) Apply for PAR 22 128 Funding Number: PAR 22 128 Agency: National Institutes of Health Category: Health Funding Amount: $150,000 |
| Limited Competition: Clinical and Translational Science Awards (CTSA) Consortium-Wide Centers: Resources for Rapid Demonstration and Dissemination (U24 Clinical Trials Optional) Apply for PAR 22 122 Funding Number: PAR 22 122 Agency: National Institutes of Health Category: Health Funding Amount: $3,000,000 |
| The Role of Dentistry in the Prevention of Opioid Drug Misuse and Abuse (UG3/UH3 Clinical Trial Optional) Apply for RFA DE 23 010 Funding Number: RFA DE 23 010 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| Limited Competition: Small Grant Program for NIAMS K01, K08, K23, and K25 Recipients (R03) (Clinical Trials Not Allowed) Apply for PAR 22 119 Funding Number: PAR 22 119 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Advancing HIV/AIDS Research at the Intersection of Oral and Mental Health (R21 Clinical Trial Not Allowed) Apply for RFA DE 23 003 Funding Number: RFA DE 23 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Advancing HIV/AIDS Research at the Intersection of Oral and Mental Health (R01 Clinical Trial Not Allowed) Apply for RFA DE 23 002 Funding Number: RFA DE 23 002 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Centers of Excellence in Genomic Science (RM1 Clinical Trial Optional) Apply for PAR 22 107 Funding Number: PAR 22 107 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Center for Coordination of Analysis, Science, Enhancement, and Logistics (CASEL) in Tobacco Regulatory Science (U54 Clinical Trial Not Allowed) Apply for RFA OD 22 003 Funding Number: RFA OD 22 003 Agency: National Institutes of Health Category: Health Funding Amount: $3,800,000 |
| NEI Regenerative Medicine Clinical Trial Planning Grant (R34 - Clinical Trials Not Allowed) Apply for PAR 22 135 Funding Number: PAR 22 135 Agency: National Institutes of Health Category: Health Funding Amount: $150,000 |
| Tobacco Centers of Regulatory Science (TCORS) for Research Relevant to the Family Smoking Prevention and Tobacco Control Act (U54 Clinical Trial Optional) Apply for RFA OD 22 004 Funding Number: RFA OD 22 004 Agency: National Institutes of Health Category: Health Funding Amount: $4,000,000 |
| Development of HIV Broadly Neutralizing Antibody Susceptibility Assays (R61/R33 Clinical Trial Not Allowed) Apply for RFA AI 22 022 Funding Number: RFA AI 22 022 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA RM 22 009", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.