Opportunity Information: Apply for RFA CA 18 011
The SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Focused Technologies Toward Commercialization (R44, Clinical Trial Optional) is a National Institutes of Health opportunity, led through the National Cancer Institute, designed to help small businesses push promising cancer-related technologies from a completed SBIR or STTR Phase II project into the next, commercialization-focused stage. It is essentially a "bridge" mechanism meant to close the gap between federally supported early development and the expensive, high-risk work that typically follows when a product needs to be validated, scaled, prepared for regulatory pathways, and positioned for market entry.
This FOA is specifically for small business concerns that already have a technology funded under an SBIR or STTR Phase II award from any federal agency, not just NIH. The proposed Phase IIB Bridge project must fit into one of three cancer-focused categories: cancer therapeutics; cancer imaging technologies, interventional devices, and/or in vivo diagnostics; or in vitro and ex vivo cancer diagnostics and prognostics. In practical terms, that means the program is looking for technologies that are clearly aimed at preventing, detecting, diagnosing, monitoring, or treating cancer, and that are far enough along that an infusion of additional support could move them into real-world commercialization milestones.
A central goal of the program is to encourage and formalize partnerships between the Phase II awardee and outside capital sources, such as third-party investors or strategic corporate partners. The FOA makes it clear that applicants are expected to bring in independent third-party funding and to describe it in a required Commercialization Plan. That plan should lay out what external funding has already been secured or is expected during the Phase IIB project period, along with how the combined resources will be used to advance the product toward market readiness. A key expectation is that the amount of third-party funding will be equal to or greater than the NCI funding requested over the full Phase IIB Bridge project period, reinforcing that this award is intended to leverage private or non-NCI investment rather than replace it.
From a development standpoint, projects can cover either preclinical or clinical stages depending on what is appropriate for the technology and its readiness level. Clinical trials are allowed under this announcement, but they are not mandatory, which gives applicants flexibility: some projects may focus on final preclinical validation, manufacturing scale-up, design controls, verification and validation testing, regulatory submissions, or other steps needed to de-risk the technology before human studies, while others may use the bridge funding to support clinical evaluation when that is the logical next step.
Eligibility is limited to small businesses. Non-U.S. (foreign) institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible to apply. However, foreign components may be allowed under NIH policy definitions and conditions, so applicants with any international collaboration or activity would need to check the NIH Grants Policy Statement and the full funding announcement language to understand what is permissible and how it must be justified.
The source details indicate this is a discretionary grant opportunity (Funding Instrument: Grant) under NIH, with CFDA numbers 93.394 and 93.395. The funding opportunity number is RFA-CA-18-011, originally posted on 2018-02-14, with an original closing date of 2018-08-15. The overall intent is to speed commercialization of cancer-focused technologies by pairing continued federal support with meaningful third-party investment, while requiring a clear, credible commercialization strategy that explains the pathway to real patient and market impact.Apply for RFA CA 18 011
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Focused Technologies Toward Commercialization (R44 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on 2018-02-14.
- Applicants must submit their applications by 2018-08-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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| Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43 Clinical Trial Optional) Apply for PAR 18 717 Funding Number: PAR 18 717 Agency: National Institutes of Health Category: Education, Health Funding Amount: $280,000 |
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