Opportunity Information: Apply for RFA HD 21 026
The Maternal and Pediatrics Precision in Therapeutics Hub (MPRINT) (P50 Clinical Trial Optional) funding opportunity (RFA-HD-21-026) is a National Institutes of Health program from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) within the Department of Health and Human Services. It supports the creation of Centers of Excellence in Therapeutics (CETs) that together form a coordinated national hub focused on improving therapeutics research and capabilities in obstetrics, lactation, and pediatrics, with a clear emphasis on strengthening the inclusion of people with disabilities in research and therapeutic development. The basic idea is to build a small network of highly capable centers that can both conduct high-impact research and function as a shared national resource for the broader scientific, regulatory, and drug development communities.
At the core of MPRINT is the goal of advancing precision therapeutics for pregnant and lactating people and for children, areas where drug dosing, safety, and effectiveness evidence is often limited or incomplete. The FOA envisions these CETs as places that can tackle major gaps in knowledge and technical expertise in maternal and pediatric pharmacology and therapeutics. Rather than operating in isolation, the funded centers are expected to collaborate with one another and closely coordinate with a separate, dedicated coordinating entity called the MPRINT Knowledge and Research Coordination Center (KRCC; referenced as RFA-HD-21-025). The KRCC is positioned as the primary public-facing component of the hub, meaning it serves as the outward portal for disseminating information and connecting stakeholders to the CETs resources, expertise, tools, and research outputs.
The program supports a wide range of scientific approaches. CETs may propose cutting-edge clinical, translational, basic science, and/or data science research, and the clinical trial component is optional under this announcement. Beyond producing publishable findings, the centers are also expected to generate practical, reusable resources for the field, such as novel tools, methodologies, datasets, models, or analytic approaches that help accelerate research and regulatory science in maternal and pediatric therapeutics. In other words, the deliverables are intended to be both scientific (new knowledge) and infrastructural (capabilities and tools that other groups can adopt), ultimately improving how therapeutics are evaluated, optimized, and applied in these populations.
In terms of the bigger picture, MPRINT is designed to work as a national resource that aggregates and expands existing knowledge while also filling in missing evidence. By organizing expertise and outputs across multiple centers and linking them through a central coordination and dissemination function (the KRCC), the hub aims to make it easier for researchers, regulators, and drug developers to access specialized maternal and pediatric therapeutics expertise, identify gaps, use validated tools, and translate findings into better-informed therapeutic decisions. The emphasis on regulatory science signals that the work is intended to be useful not only academically but also in contexts where evidence standards, labeling, dosing guidance, and safety evaluations matter.
The opportunity uses the NIH P50 specialized center grant mechanism, categorized as a discretionary grant in the Health, Income Security and Social Services activity area (CFDA 93.865). The award ceiling listed is $850,000, and the opportunity anticipated making 2 awards. Eligible applicants are broad and include many types of public and private entities: state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other than small businesses); and other entities as allowed under the announcement. The FOA creation date is August 3, 2020, and the original closing date listed is November 30, 2020.
Overall, this FOA is about building a tightly connected set of specialized centers that can push forward the science of maternal and pediatric therapeutics while also serving as a practical national platform for sharing expertise, tools, and evidence. The expectation is not just to conduct strong research, but to help the entire ecosystem (research, regulatory science, and drug development) move faster and with greater confidence when studying and applying therapeutics in pregnancy, lactation, and childhood, while improving inclusion of people with disabilities.Apply for RFA HD 21 026
- The Department of Health and Human Services, National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Maternal and Pediatrics Precision in Therapeutics Hub (MPRINT) (P50 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on Aug 03, 2020.
- Applicants must submit their applications by Nov 30, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $850,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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